A transcriptional cofactor‐mediated dependency module

In this newest podcast episode, Dr Charles de Bock hosts Dr Thomas Mercher and Dr Alexandre Fagnan. This episode is based on their recent paper, “The ETO2 transcriptional co-factor maintains acute leukemia by driving a MYB/EP300-dependent stemness program”, highlighting ETO2 activated gene transcription and how this affects erythroleukemia. The discussion traces the journey from part of Dr Fagnan’s PhD project (2022 EHA Junior Grant awardee), the findings in the paper and what may lie beyond.

This episode is also available on our YouTube channel .

Listen and enjoy casual, insightful discussions about #hematology research.

You can find the referenced article, “The ETO2 transcriptional co-factor maintains acute leukemia by driving a MYB/EP300-dependent stemness program” in full and open access, here on the HemaSphere website.