Episode 3.2 - Navigating Neutropenia: New Guidelines Explained

In this episode of the HemaSphere podcast, host Dr Charles De Bock discusses the newly published Guidelines on the treatment of neutropenias with co-authors Dr. Francesca Fioredda and Dr. Eleni Papadaki. They explore the importance of these international guidelines, the challenges faced in gathering evidence, and the consensus-building process among experts. The conversation also delves into treatment options, including gene therapy and stem cell transplants, while highlighting the need for more research in the field.

"European guidelines on treatment and supportive measures in chronic neutropenias: A consensus between the European Hematology Association and the EuNet-INNOCHRON COST Action based on a systematic evidence review”, is on our website, all major podcast platforms, and YouTube. Listen and enjoy casual, insightful discussions about #hematology research.

You can find the referenced article, in full and open access, here on the HemaSphere website.

This is a follow up to the neutropenia Guidelines published in 2023, which focused on diagnosis and management. Both the previous Guidelines and the podcast episode can be found here.

Other papers referenced:

Ritter MU, Nasri M, Dannenmann B, et al. Comparison of Gene-Editing Approaches for Severe Congenital Neutropenia-Causing Mutations in the ELANE Gene. CRISPR J. 2024 Oct;7(5):258-271. doi: 10.1089/crispr.2024.0006. PMID: 39436283. https://pubmed.ncbi.nlm.nih.gov/39436283/

Nasri M, Ritter MU, Mir P, Dannenmann B, et al. CRISPR-Cas9n-mediated ELANE promoter editing for gene therapy of severe congenital neutropenia. Mol Ther. 2024 Jun 5;32(6):1628-1642. doi: 10.1016/j.ymthe.2024.03.037. Epub 2024 Mar 30. PMID: 38556793; PMCID: PMC11184331. https://pubmed.ncbi.nlm.nih.gov/38556793/